Cleanance Comedomed, an innovation from Laboratoires Eau Thermale Avène with proven effectiveness from seven days*, targets invisble &visible blemishes with a unique action, and limits their reappearance. Expert skincare for oily, blemish-prone skin, Cleanance Comedomed is formulated using Comedoclastin™, a plant extract from the seeds of milk thistle. This active ingredient with patented properties** directly targets blackheads, reduces existing blemishes and prevents new ones from appearing. Cleanance Comedomed, applied twice a day, reduces blemishes within seven days* and provides clinically proven*** anti-reappearance action. Can be used by adults and teenagers from the age of 12. Non-comedogenic, high-tolerance* for blemish-prone skin, its fast-absorbing, non-greasy texture leaves the skin mattified. Cleanance Comedomed can be used alone, alongside other products, or after acne medication (excluding oral isotretinoin).